Development of Mechanisms Associated With Neurogenic-Mediated Skin Inflammation During the Growth of Rats

作者：Ohshima Mihoko; Miyake Mio; Takeda Masanori; Muto Taichiro; Ueda Norishi; Ito Komei; Sakamoto Tatsuo^*

来源：Pediatric Research, 2010, 67(4): 363-368.

DOI：10.1203/PDR.0b013e3181d026a5

Neurogenic-mediated inflammation may be associated with several inflammatory skin diseases including atopic dermatitis. However, age-dependent differences in neurogenic-mediated skin responses are not fully understood. We compared skin plasma leakage in rats aged 2 and 8 wk, which was induced by topical capsaicin, topical formalin, and intracutaneous substance P, whose effects are mediated via tachykinin NK1 receptors. Evans blue dye extravasation served as an index of the increase in skin vascular permeability. Capsaicin, formalin, and Substance P caused a skin response in a dose-dependent manner in both age groups. However, the skin response was much greater in adults than in Pups. In addition. the localization of sensory C-fibers and tachykinin NK1 receptors in the skin was investigated by immunofluorescent staining with antisubstance P and antitachykinin NK1 receptor antibodies, respectively. Substance P-immunoreactive nerves were detected throughout the dermis and tachykinin NK1 receptors were mainly detected in blood vessel walls in the dermis in both age groups. However, they were more sparsely distributed in pups. In conclusion, the weak neurogenic-mediated skin inflammation in pups is probably because of immature neural mechanisms associated with skin inflammation such as reduced innervation of sensory C-fibers and low expression of tachykinin NK1 receptors. (Pediatr Res 67: 363-368, 2010)

• 出版日期2010-4
• 单位国家安全生产监督管理总局信息研究院