A comparison of oxycodone prolonged-release vs. oxycodone plus naloxone prolonged-release after laparoscopic hysterectomy

作者：Comelon M^*; Wisloeff Aase K; Raeder J; Draegni T; Undersrud H; Qvigstad E; Bjerkelund C E; Lenz H

来源：Acta Anaesthesiologica Scandinavica, 2013, 57(4): 509-517.

DOI：10.1111/aas.12051

Background Targiniq (R), an oxycodone prolonged-release (PR) formulation combined with the opioid antagonist naloxone PR, aims to prevent opioid-induced constipation without impairing the analgesic efficacy. This has been confirmed during prolonged use in chronic pain or cancer patients. The purpose of our study was to compare clinical effects of oxycodone PR with oxycodone PR+naloxone PR for short-term post-operative pain management. Methods This randomised, double-blind, prospective study included 85 women undergoing laparoscopic hysterectomy. The two groups received either oxycodone PR 10mg or oxycodone PR 10mg+naloxone PR 5mg as pre-medication and twice daily for 3 days. As rescue analgesic, the patients received oxycodone intravenous during the first 24h post-operatively and oxycodone tablets in the 2472-h period. Constipation, other side effects, pain and satisfaction were registered during the first 7 post-operative days. Results Demographic, pre- and perioperative variables and the use of rescue analgesics were similar in the groups. There were no significant differences in variables related to constipation. In the oxycodone PR+naloxone PR group, 25% had no defecation during the first 72h post-operatively, compared with 20% in the oxycodone PR group (mean 1.2 +/- 1.1 vs. 2.1 +/- 2.4 defecations). Other opioid-induced effects and side effects showed no significant differences. Only 7% were dissatisfied with their oral pain treatment. Conclusion Addition of naloxone to oxycodone PR tablets in a pain regimen administered twice daily the first three post-operative days had no significant clinical effects on constipation or other variables during the first week after hysterectomy.

• 出版日期2013-4