A New Lnc in Metastasis: Long Noncoding RNA Mediates the ProMetastatic Functions of TGF-beta

作者：Li Wenyang; Kang Yibin^*

来源：Cancer Cell, 2014, 25(5): 557-559.

DOI：10.1016/j.ccr.2014.04.014

TGF-beta signaling promotes metastasis by controlling the expression of downstreamtarget genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-beta-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.

• 出版日期2014-5-12