A Simple and Efficient Synthesis of the Antimigraine Drug Lomerizine

作者：Narsaiah A Venkat^*; Kumar J Kranthi

来源：Synthesis, 2010, (12): 1989-1991.

DOI：10.1055/s-0029-1218749

• keto reduction
• calcium chloride
• trimethoxybenzyl bromide
• piperazine

The synthesis of the antimigraine drug 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine has been carried out in very good yields. The five-step synthesis started from bis(4-fluorophenyl)methanone. This route can be applied for large-scale preparation of lomerizine.

• 出版日期2010-6