Asymmetric Synthesis of Chiral 9,10-Dihydrophenanthrenes Using Pd-Catalyzed Asymmetric Intramolecular Friedel-Crafts Allylic Alkylation of Phenols

作者：Suzuki Yuta; Nemoto Tetsuhiro; Kakugawa Kazumi; Hamajima Akinari; Hamada Yasumasa^*

来源：Organic Letters, 2012, 14(9): 2350-2353.

DOI：10.1021/ol300770w

We developed a novel asymmetric synthetic method for multisubstituted 9,10-dihydrophenanthrenes based on the Pd-catalyzed asymmetric intramolecular Friedel-Crafts allylic alkylation of phenols, which produces 10-vinyl or 10-isopropenyl chiral 9,10-dihydrophenanthrene derivatives in high yield with up to 94% ee.

• 出版日期2012-5-4