Neuronal Activity-Dependent Regulation of MicroRNAs

作者：Sim Su Eon; Bakes Joseph; Kaang Bong Kiun^*

来源：Molecules and Cells, 2014, 37(7): 511-517.

DOI：10.14348/molcells.2014.0132

• high-throughput screening
• miRNA induction
• miRNA turnover
• neuronal activity
• NMDAR

MicroRNAs are non-coding short (similar to 23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may fine-tune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.

• 出版日期2014-7-31