A graftable LDV peptidomimetic: Design, synthesis and application to a blood filtration membrane

作者：Momtaz Maryam; Rerat Vincent; Gharbi Sonia; Gerard Estelle; Pourcelle Vincent; Marchand Brynaert Jacqueline^*

来源：Bioorganic & Medicinal Chemistry Letters, 2008, 18(3): 1084-1090.

DOI：10.1016/j.bmcl.2007.12.006

• alpha(4)beta(1) integrin ligand
• LDV peptidomimetic
• PVDF filter
• surface wet chemistry
• leukocyte depletion

A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenylpropionic acid, as alpha(4)beta(1) (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention.

• 出版日期2008-2-1