Novel anti-beta-functionalized gamma,delta-unsaturated amino acids via a thio-Claisen rearrangement

作者：Liu Zhihua; Qu Hongchang; Gu Xuyuan; Lee Kwang Soo; Grossman Bryan; Kumirov Vlad K; Hruby Victor J^*

来源：Tetrahedron Letters, 2010, 51(27): 3518-3520.

DOI：10.1016/j.tetlet.2010.04.102

A significantly improved thio-Claisen rearrangement method was developed for preparing anti-13-functionalized gamma,delta-unsaturated amino acids, which are extremely useful nonproteinogenic amino acids used in chemistry and biology research. The mild reaction condition successfully introduced base labile functional groups into the amino acids with excellent anti/syn selectivities.

• 出版日期2010-7-7