A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD

作者：Donohue James F^*; Anzueto Antonio; Brooks Jean; Mehta Rashmi; Kalberg Christopher; Crater Glenn

来源：Respiratory Medicine, 2012, 106(7): 970-979.

DOI：10.1016/j.rmed.2012.03.012

• Long-acting muscarinic receptor antagonist
• Long-acting bronchodilator
• Anticholinergic
• Chronic obstructive pulmonary disease
• G5K573719

Background: This study evaluated the dose-response and dosing interval of the novel long-acting muscarinic receptor antagonist (LAMA) GSK573719 in patients with COPD. %26lt;br%26gt;Methods: This randomized, double-blind, placebo-controlled, 3-way cross-over, incomplete block study evaluated 5 once-daily doses of GSK573719 (62.5-1000 mu g), 3 twice-daily doses (62.5-250 mu g), and open-label tiotropium for 14 days in patients (N = 176) with COPD (FEV1 of 35-70% predicted). The primary endpoint was morning trough FEV1 at Day 15. Secondary endpoints included 0-24 h weighted mean FEV1 and serial FEV1 values over 28 h. Safety measures and pharmacokinetics were assessed. %26lt;br%26gt;Results: All once-daily doses of GSK573719 significantly increased trough FEV1 at Day 15 with improvements ranging from 95 to 186 mL over placebo (p %26lt;= 0.006), from 79 to 172 mL with twice-daily dosing (p %26lt;= 0.03), and 105 mL with tiotropium (p = 0.003). No clear dose ordering was observed. Once-daily doses significantly (p %26lt; 0.001) increased 0-24 h weighted mean FEV1 at Day 14 by 131-143 mL over placebo, comparable to increases with the twice-daily doses (120-142 mL) and tiotropium (127 mL). Significant reductions in rescue albuterol use and improvements in FVC were also observed with once-daily dosing. Plasma C-max occurred within 5-15 min of dosing after which the drug was rapidly cleared and eliminated. GSK573719 was well tolerated, with no apparent treatment-related changes in vital signs, ECG and Hotter assessments, or clinical laboratory parameters. %26lt;br%26gt;Conclusion: Once-daily dosing with GSK573719 in COPD provides clinically significant and sustained improvement in lung function over 24 h with similar efficacy to twice-daily dosing.

• 出版日期2012-7