A General Method for the Enantioselective Synthesis of alpha-Chiral Heterocycles

作者:Le Phong Q; Nguyen Thien S; May Jeremy A*
来源:Organic Letters, 2012, 14(23): 6104-6107.
DOI:10.1021/ol3030605

摘要

The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er%26apos;s are observed for a host of common heteroaryls.

  • 出版日期2012-12-7