A unique macrolactam derivative via a [4+6]-cycloaddition from Streptomyces niveus

作者：Li, Liya; Cai, Yaping; Jiang, Yi; Liu, Jiang; Ma, Jian; Yuan, Chunhui; Mu, Yu; Han, Li^*; Huang, Xueshi

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(6): 1599-1604.

DOI：10.1016/j.bmcl.2016.02.002

• Macrolactam
• Streptomyces niveus
• Cytotoxicity
• Cycloaddition
• In vitro

One new macrolactam derivative, nivelactam (1) and one new polyenoic acid derivative, niveamide (2), along with two other known 20-atom macrolactams (3 and 4) were isolated from the fermentation broth of Streptomyces niveus, which obtained from the forest soil in northeastern China. The structures of 1 and 2 were elucidated on the basis of HRESIMS, IR, and NMR spectroscopic data analyses. Compound 1 was proposed as an intramolecular [4+6]-cycloaddition product of 3 by S. niveus, and displayed moderate cytotoxic activity against a panel of human tumor cell lines in vitro, with IC50 values ranging from 3.76 +/- 0.58 to 15.02 +/- 2.81 mu M.

• 出版日期2016-3-15
• 单位东北大学; 云南大学