MicroRNA Hsa-miR-125a-3p Activates p53 and Induces Apoptosis in Lung Cancer Cells

作者：Jiang, Lili; Chang, Jihong; Zhang, Qingfu; Sun, Limei; Qiu, Xueshan^*

来源：Cancer Investigation, 2013, 31(8): 538-544.

DOI：10.3109/07357907.2013.820314

• Carcinogenesis
• Lung cancer
• Tumor biology
• Tumor cell Biology
• Tumor Suppressors

The mature microRNA hsa-miR-125a-3p is derived from the 3' end of pre-miR-125a. Here, we reported that hsa-miR-125a-3p suppressed proliferation and induced apoptosis in A549 cells. In addition, wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-3p over-expression. Moreover, blocking wild-type p53 attenuated the effect of hsa-miR-125a-3p on apoptosis but could not restore completely. In p53-deficient cell line H1299, hsa-miR-125a-3p still induced apoptosis. Taken together, these data suggest that hsa-miR-125a-3p induces apoptosis not only via the p53 pathway in human lung cancer cells. These results provide new insight into the roles of the miR-125a family in lung cancer.

• 出版日期2013-10
• 单位辽东学院; 中国医科大学