A trial of oral nifedipine and oral labetalol in preeclampsia hypertensive emergency treatment

作者：Duro Gomez Jorge; Rodriguez Marin Ana B; Gimenez de Azcarete Mercedes; Duro Gomez Lourdes; Hernandez Angeles Claudio; Arjona Berral Jose E; Castelo Branco Camil^*

来源：Journal of Obstetrics and Gynaecology, 2017, 37(7): 864-866.

DOI：10.1080/01443615.2017.1308321

• Nifedipine
• labetalol
• severe hypertension
• hypertensive emergency
• pregnancy
• pre-eclampsia
• safety

This observational retrospective cohort study was conducted to compare oral nifedipine and labetalol for emergency treatment of hypertension in preeclamptic patients. Time (minutes) and necessary doses were outlined to achieve blood pressure lower than 150/95 mmHg. In 14 patients with preeclampsia, 55 hypertensive emergencies were identified (BP >150/95). Of these emergencies, 43 were treated with oral nifedipine 10 mg (10 patients) and 12 with oral labetalol 100 mg (4 patients). To achieve a target blood pressure under 150/95, these doses were repeated as necessary every 20 min, up to a maximum of 4 doses. Oral nifedipine reduced BP more rapidly (31.30 vs. 53.50 min, p = .03). No maternal or foetal adverse events were observed and no major differences were found according to the type of delivery. Oral nifedipine is faster than and at least as safe as labetalol in pre-eclampsia hypertensive emergency treatment.

• 出版日期2017-10