科研之友
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摘要
In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (ligand 1). Ln(3+) complexes of 1 have one inner-sphere water molecule. The r(1) relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange by a factor of 3 compared to that for GdDOTA. In addition, complexes Nd1 and Yb1 exhibit significant NIR emission in aqueous solutions, which indicates that the tropone unit is an efficient sensitizer for these Ln(3+) ions. Therefore, this new ligand is a promising platform for the design of Ln(3+)-based dual MR/optical imaging probes.
- 出版日期2017-11-24
