Novel strategies for preventing viral hepatitis C recurrence after liver transplantation

作者：Stoll Keller Francoise^*; Fafi Kremer Samira; Wolf Philippe; Doffoel Michel; Baumert Thomas

来源：Bulletin de l Academie Nationale de Medecine, 2008, 192(8): 1657-1667.

• HEPATITIS
• LIVER TRANSPLANTATION
• RECURRENCE
• VIRUS INTERNALISZATION
• ANTI BODIES/ANALYSIS

Hepatitis C virus (HCV) is a major cause of chronic liver disease. About 170 million people worldwide are chronically infected No preventive or therapeutic vaccine is available. Current antiviral combinations based on pegylated interferon alpha (IFN-proportional to) and ribavirin have limited efficacy, poor tolerability and high cost. End-stage liver disease due to chronic HCV infection is a leading indication for liver transplantation (LT). However, re-infection of the liver graft is inevitable, with a high risk of cirrhosis within 5 years. To infect the graft, circulating virions need to attach to and enter hepatocytes, via viral envelope glycoproteins E1-E2. E1-E2 can react with cell receptors despite the presence of neutralizing antibodies. Using the HCV pseudoparticle model system, we found that viral strains selected after liver transplantation are characterized by high infectivity and that they are poorly neutralized by autologous post-transplant serum. A better understanding of the early steps of viral attachment and escape from neutralizing antibodies could lead to novel antiviral strategies.

• 出版日期2008-11