Diltiazem Hydrochloride Trapping in Poly(methacrylic Acid-Co-Acrylamide) Microparticles: In-Vitro Drug Delivery Studies

作者：Moinuddin F; Mondal Subodh; Satish C S^*

来源：International Journal of Polymeric Materials, 2013, 62(9): 469-474.

DOI：10.1080/00914037.2012.734347

• Diffusion
• diltiazem hydrochloride
• drug release
• microparticles

Microparticles based on poly(methacrylic acid-co-acrylamide) crosslinked with N,N'-methylene bisacrylamide were prepared by free radical polymerization using varying amounts of acrylamide (AAm), methacrylic acid (MAA), and N,N'-methylene bisacrylamide (NNMBA). The microparticles were loaded with antihypertensive drug, diltiazem hydrochloride (water-soluble), to investigate their release characteristics. The release behavior in pH 2.0 was much slower than in buffer solution at pH 7.4. The diffusion coefficients ranged from 08.03x106 to 25.40x106cm2 min1 in pH 2.0 buffer and from 02.41x104 to 35.25x104cm2 min1 in pH 7.4 buffer.

• 出版日期2013-5-20