Adipose tissue attenuation as a marker of adipose tissue quality: Associations with six-year changes in body weight

作者：Therkelsen Kate E; Pedley Alison; Rosenquist Klara J; Hoffmann Udo; Massaro Joseph M; Murabito Joanne M; Fox Caroline S^*

来源：Obesity, 2016, 24(2): 499-505.

DOI：10.1002/oby.21337

• epidemiology
• adipose tissue
• population studies
• obesity

ObjectiveWeight gain is associated with fat volume increases, but associations with fat quality are less well characterized The associations of weight change with visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volume and attenuation were investigated.
MethodsComputed tomography abdominal scans were acquired on a Framingham Heart Study subset (N=836; 40.2% women; mean age 45.7years), a mean of 6.1years apart. Fat attenuation estimated fat quality.
ResultsMean weight change was +2.0 (SD 6.8; IQR -0.7, 5.0)kg in women and +2.7 (SD 6.0; IQR -0.5, 5.4)kg in men. Per 2.5kg weight increase in women, VAT volume increased 126cm(3) (95% CI, 112-140, p<0.0001), SAT volume increased 258cm(3) (95% CI, 239-278, p<0.0001), and fat attenuation decreased (i.e., fat quality worsened) in VAT and SAT (p<0.0001). Increasing VAT volume was associated with decreasing fat attenuation even after accounting for weight change. Relative to weight-stable women (n=129), women who lost >2.5kg (n=58) had smaller SAT attenuation decreases (p<0.0001). Similar patterns were seen in men.
ConclusionsWeight gain was associated with decreases in fat attenuation independent of VAT and SAT volume changes. These findings highlighted the associations of weight gain and worsening fat attenuation, suggesting fat attenuation may be dynamic.

• 出版日期2016-2