A(1)A(2)BO and Rh gene frequencies among six populations of Jammu and Kashmir, India

作者：Fareed Mohd; Hussain Ruqaiya; Shah Ahsana; Afzal Mohammad^*

来源：Transfusion and Apheresis Science, 2014, 50(2): 247-252.

DOI：10.1016/j.transci.2014.01.014

• Blood groups
• Rhesus protein
• Human population
• Allele frequency
• Health and disease

A study was undertaken to record gene frequencies of ABO blood groups, their subtypes and Rh antigen for six different endogamous groups including a tribal population. The ABO phenotypic frequency varies among six different populations showing significant difference (p < 0.0005). Gujjar and Bakarwal (a tribal population) shows highest (42.29%) of B blood phenotypes. A(1) is the highest among Syeds (39.31%), O blood group frequency highest among Mughals (43.23%) and A(1)B and A(2)B are rare phenotypes showing very low frequency among all populations. The pattern of allele frequencies (p < 0.025) is in order of I-O > I-B > I-A1 > I-A2 except Syeds (I-O > I-A1 > I-B > I-A2). The rhesus protein (Rh) phenotypic frequency (p < 0.01) shows significant increase in Rh(D) positive (87.86% in Syed to 96.03% in Khan) among all populations. The Rh allele (p < 0.05) and genotype (p < 0.02) frequencies shows a significant difference. Heterozygosity for Rh protein is less than homozygosity among six populations. The result from this study provides information on the genetic variation in blood antigens and rhesus protein among human populations inhabiting Jammu and Kashmir.

• 出版日期2014-4