A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer-Sized Polymer Beads

作者：Bai Meng Yi^*; Moran Christine H; Zhang Lei; Liu Changjun; Zhang Yu; Wang Lihong V; Xia Younan

来源：Advanced Functional Materials, 2012, 22(4): 764-770.

DOI：10.1002/adfm.201102582

• hollow colloidal particle
• contrast agent
• encapsulation

Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro-computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95 degrees C) slightly above the glass-transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents.

• 出版日期2012-2-22