Association between D-dimer level and portal venous system thrombosis in liver cirrhosis: a retrospective observational study

作者：Dai Junna; Qi Xingshun; Peng Ying; Hou Yue; Chen Jiang; Li Hongyu; Guo Xiaozhong

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(9): 15296-15301.

• Portal vein thrombosis
• liver cirrhosis
• D-dimer
• fibrinolysis
• pathogenesis

Objective: This study aimed to explore the association between D-dimer levels and presence of portal venous system thrombosis (PVST) in liver cirrhosis. Methods: All consecutive patients with a diagnosis of liver cirrhosis who underwent D-dimer test were retrospectively enrolled. Normal reference range of D-dimer level was 0-0.3 mu g/mL. PVST was diagnosed on the basis of contrast-enhanced computed tomography and/or magnetic resonance imaging scans. Results: Of the 66 included patients, 24 were diagnosed with PVST. Mean D-dimer level was 0.51 +/- 0.72 mu g/mL (range: 0.10-3.44). Mean D-dimer level was not significantly different between PVST and non-PVST groups (0.68 +/- 0.93 mu g/mL versus 0.41 +/- 0.56 mu g/mL, P=0.146). Area under the receiver operating curve for D-dimer level for predicting the presence of PVT was 0.606 (95% confidence interval: 0.478-0.724, P=0.1393). The optimal cutoff value for D-dimer was 0.22 with a sensitivity of 58.3% and a specificity of 69.0%. The subgroup analyses of patients without splenectomy or those with different Child-Pugh classes demonstrated no significant difference in the D-dimer level between PVST and non-PVST groups. Conclusion: D-dimer might not be useful to identify the presence of PVST in liver cirrhosis. However, given the retrospective nature of this study, further well-designed prospective study should be necessary to confirm this finding.

• 出版日期2015
• 单位大连医科大学