A new stilbene glycoside from the n-butanol fraction of Veratrum dahuricum

作者：Dai, Li-Min^*; Tang, Jian; Li, Hui-Liang; Shen, Yun-Heng; Peng, Cai-Yun; Zhang, Wei-Dong

来源：Chemistry of Natural Compounds, 2009, 45(3): 325-329.

DOI：10.1007/s10600-009-9352-8

• Veratrum dahuricum
• stilbene
• 5-methylresveratrol-3,4 '-O-beta-D-diglucopyranoside
• platelet aggregation

A new stilbene glycoside, 5-methylresveratrol-3,4'-O-beta-D-diglucopyranoside (1), was isolated from the n-butanol fraction of the rhizomes of Veratrum dahuricum, together with five known stilbenoids: resveratrol-3-O-beta-D-glycoside (2), 4'-methylresveratrol-3-O-beta-D-glycoside (3), oxyresveratrol-4'-O-beta-D-glycoside (4), oxyresveratrol-3-O-beta-D-glycoside (5), and oxyresveratrol-3,4'-O-beta-D-diglycoside (6), and found for the first time in the investigated plant. The structures of six isolates were identified on the basis of 1D and 2D NMR data. Compounds 1-6 showed platelet aggregation inhibition, and compound 1 had an IC50 value of 383.6 mu M against platelet aggregation induced by AA.

• 出版日期2009-5
• 单位湖南中医药大学; 中国人民解放军第二军医大学; 上海交通大学