Nuclear Factor-kappa B modulates cellular glutathione and prevents oxidative stress in cancer cells

作者：Meng Qinghang; Peng Zhimin; Chen Liang; Si Jutong; Dong Zhongyun; Xia Ying^*

来源：Cancer Letters, 2010, 299(1): 45-53.

DOI：10.1016/j.canlet.2010.08.002

• NF-kappa B
• Glutathione
• Arsenic
• Leukemia
• Prostate cancer
• Oxidative stress

The NF-kappa B is best known for its role in inflammation Here we show that constitutive NF-kappa B activity in cancer cells promotes the biosynthesis of redox scavenger glutathione (GSH) which in turn confers resistance to oxidative stress Inhibition of NF-kappa B significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-kappa B activities Concomitantly NF-kappa B inhibition by pharmacological and molecular means sensitizes NF-kappa B positive cancer cells to chemically-induced oxidative stress and death We propose that inhibition

• 出版日期2010-12-18