A New Method for Using Radiopaque Sclerosing Foam to Treat Venous Malformations

作者：Li, Kai; Liu, Yi-Ran; Chen, An-Wei; Liu, Shao-Hua^*

来源：Dermatologic Surgery, 2015, 41(6): 726-730.

DOI：10.1097/DSS.0000000000000363

• SODIUM TETRADECYL SULFATE
• VASCULAR MALFORMATIONS
• EUROPEAN GUIDELINES
• SCLEROTHERAPY
• MANAGEMENT
• MORRHUATE
• DIAGNOSIS
• HEAD

BACKGROUND @@@ Sclerosing foam is recommended to treat venous malformations (VMs). However, determining the precise dosage for satisfactory efficacy and few side effects are still challenging. @@@ OBJECTIVE @@@ To develop a new method of preparing sclerosing foam by adding contrast agent to treat patients with VMs visibly and precisely under radiologic guidance. @@@ MATERIALS AND METHODS @@@ Sclerosant (polidocanol) and contrast agent (iopromide) were mixed to prepare a new sclerosing foam according to Tessari method, and different ratios of the 2 materials were used to study the stability (half-life) of the produced foams. X-ray absorption of the radiopaque foams was observed during patient treatment with digital subtraction angiography (DSA). @@@ RESULTS @@@ The foams generated with the new method demonstrated a high x-ray absorption under DSA. The foam half-life among groups varied. The ratio of iopromide/polidocanol at 1:2 had a significantly longer half-life than the 1:1 or polidocanol-only group. The 1:2 group had a relative high x-ray absorption and was radiopaque to allow visualization of the sclerosing foam and lesion with DSA. @@@ CONCLUSION @@@ Mixing contrast agent with sclerosant to prepare radiopaque foams is a new method for treating complex VMs with DSA, and a ratio of 1:2 is recommend for polidocanol and iopromide.

• 出版日期2015-6
• 单位山东大学