alpha-amidation of cyclic ethers catalyzed by simple copper salt and a mild and efficient preparation method for alpha,pi-amino alcohols

作者：He Ling^*; Yu Jing; Zhang Ji; Yu Xiao Qi

来源：Organic Letters, 2007, 9(12): 2277-2280.

DOI：10.1021/ol070537i

Copper(II) trifluoromethanesulfonate catalyzed the amidation of cyclic ethers with iminoiodanes under mild conditions (CH2Cl2, 40 degrees C) with good yields (up to 86% based on 97% conversion) and selectivity (only alpha-amino products were found). Subsequently, the tosylamidated products could undergo a reductive ring-opening reaction to give alpha,pi-amino alcohols.

• 出版日期2007-6-7
• 单位四川大学