Association of Kallikrein gene polymorphisms with sporadic intracranial aneurysms in the Chinese population Laboratory investigation

作者：Suo, Miaomiao; Tan, Yahui; Yu, Hui; Song, Weihua; Sun, Kai; Song, Yan; Zhang, Yinhui; Zhang, Channa; Zhu, Yufang; Pang, Qi; Hui, Rutai; Chen, Jingzhou^*

来源：Journal of Neurosurgery, 2014, 120(6): 1397-1401.

DOI：10.3171/2013.11.JNS131036

• intracranial aneurysm
• Kallikreins
• variant
• vascular disorders

Object. Variants of Kallikreins have been shown to be risk factors for intracranial aneurysm (IA) in a Finnish population. In the present study, the authors investigated the correlation between polymorphisms in the Kallikrein gene cluster and IAs in the Chinese population.
Methods. The association of Kallikrein variants (rs1722561 and rs1701946) with sporadic IAs was tested in 308 cases and 443 controls. The differences in allelic frequencies between patients and the control group were evaluated with the chi-square test.
Results. The C allele of rs1722561 showed a. significant reduction in the risk of sporadic IA (OR 0.71, 95% CI 0.53-0.95; p = 0.023). However, no association of the variant rs1701946 with sporadic IA was found (OR 0.78, 95% CI 0.57-1.06; p = 0.115).
Conclusions. The variant rs1722561 of Kallikreins might reduce the risk of sporadic IAs among individuals of Chinese Han ethnicity. This study confirms the association between Kallikreins and IAs.

• 出版日期2014-6
• 单位山东大学; 心血管疾病国家重点实验室; 中国医学科学院阜外医院; 山东省立医院; 中国医学科学院北京协和医院; 北京协和医学院