Abnormal White Matter Integrity in the Corpus Callosum among Smokers: Tract-Based Spatial Statistics

作者：Umene Nakano Wakako^*; Yoshimura Reiji; Kakeda Shingo; Watanabe Keita; Hayashi Kenji; Nishimura Joji; Takahashi Hidehiko; Moriya Junji; Ide Satoru; Ueda Issei; Hori Hikaru; Ikenouchi Sugita Atsuko; Katsuki Asuka; Atake Kiyokazu; Abe Osamu; Korogi Yukunori; Nakamura Jun

来源：PLos One, 2014, 9(2): e87890.

DOI：10.1371/journal.pone.0087890

In the present study, we aimed to investigate the difference in white matter between smokers and nonsmokers. In addition, we examined relationships between white matter integrity and nicotine dependence parameters in smoking subjects. Nineteen male smokers were enrolled in this study. Eighteen age-matched non-smokers with no current or past psychiatric history were included as controls. Diffusion tensor imaging scans were performed, and the analysis was conducted using a tract-based special statistics approach. Compared with nonsmokers, smokers exhibited a significant decrease in fractional anisotropy (FA) throughout the whole corpus callosum. There were no significant differences in radial diffusivity or axial diffusivity between the two groups. There was a significant negative correlation between FA in the whole corpus callosum and the amount of tobacco use (cigarettes/day; R = -0.580, p = 0.023). These results suggest that the corpus callosum may be one of the key areas influenced by chronic smoking.

• 出版日期2014-2-7