Antibody Kinetics in Infants Exposed to Chikungunya Virus Infection During Pregnancy Reveals Absence of Congenital Infection

作者：Ramful Duksha^*; Samperiz Sylvain; Fritel Xavier; Michault Alain; Jaffar Bandjee Marie Christine; Rollot Olivier; Boumahni Brahim; Gerardin Patrick

来源：Journal of Infectious Diseases, 2014, 209(11): 1726-1730.

DOI：10.1093/infdis/jit814

• Chikungunya virus
• pregnancy
• congenital infection
• transplacental transfer
• serum immunoglobulins G
• serology
• immunization
• neonate
• cohort study
• Kaplan-Meier

To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time: 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.

• 出版日期2014-6-1