A novel one-dimensional manganese(II) coordination polymer containing both dicyanamide and pyrazinamide ligands: Synthesis, spectroscopic investigations, X-ray studies and evaluation of biological activities

作者：Tabrizi Leila; Chiniforoshan Hossein^*; McArdle Patrick

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2015, 139: 307-312.

DOI：10.1016/j.saa.2014.12.072

• Manganese(II)
• Dicyanamide
• Pyrazinamide
• Antitumor activity
• Antibacterial activity

A novel 1D coordination polymer {[Mn(mu(1,5)-dca)(2)(PZA)(2)](PZA)(2)}(n), 1, has been synthesized and characterized by single crystal X-ray crystallography. The coordination mode of dicyanamide (dca) and pyrazinamide (PZA) ligands was inferred by IR spectroscopy. The compound 1 was evaluated for in vitro antimycobacterial and antitumor activities. It demonstrated better in vitro activity against Mycobacterium tuberculosis than pyrazinamide and its MIC value was determined. Complex 1 was also screened for its in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines. In addition, the antibacterial activity of complex 1 has been tested against Gram(+) and Gram(-) bacteria and it has shown promising broad range anti-bacterial activity.

• 出版日期2015-3-15