A repeat offender: Recurrent extraintestinal Clostridium difficile infection following fecal microbiota transplantation

作者：Gardiner Bradley J; Thorpe Cheleste M; Pinkham Nicholas V; McDermott Laura A; Walk Seth T; Snydman David R

来源：Anaerobe, 2018, 51: 68-72.

DOI：10.1016/j.anaerobe.2018.04.007

• Extraintestinal Clostridium difficile
• Fecal microbiota transplantation
• Whole genome sequencing

Extraintestinal infection with Clostridium difficile has been reported but remains uncommon. Treatment of this unusual complication is complex given the limitations of current therapeutic options. Here we report a novel case of recurrent extraintestinal C. difficile infection that occurred following fecal microbiota transplantation. Using whole genome sequencing, we confirmed recrudescence rather than reinfection was responsible. The patient ultimately responded to prolonged, targeted antimicrobial therapy informed by susceptibility testing.

• 出版日期2018-6