A Highly Efficient Palladium/Copper Cocatalytic System for Direct Arylation of Heteroarenes: An Unexpected Effect of Cu(Xantphos)I

作者：Huang Jinkun^*; Chan Johann; Chen Ying; Borths Christopher J; Baucom Kyle D; Larsen Robert D; Faul Margaret M

来源：Journal of the American Chemical Society, 2010, 132(11): 3674-+.

DOI：10.1021/ja100354j

Heteroarenes are important structural moieties in many chemical industry fields. A highly efficient Pd/Cu-catalyzed C-H arylation method for a range of heterocycles has been discovered. It was found that the key to the Success of this transformation is a combination of a palladium catalyst and a well-defined copper cocatalyst. The efficiency and low loadings of catalyst (0.25 mol %) and cocatalyst (1 mol %) together with the mild reaction conditions demonstrate this method to be practically useful and mechanistically interesting.

• 出版日期2010-3-24