Direct cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids into fused pyrrolizinones

作者：Aiello Francesca^*; Garofalo Antonio; Grande Fedora

来源：Tetrahedron Letters, 2010, 51(50): 6635-6636.

DOI：10.1016/j.tetlet.2010.10.060

• Fused pyrrole derivatives
• Ring closure reactions
• Friedel-Crafts acylation
• Phosgene

A series of fused heterocyclic compounds based on a pyrrolizinone structure have been prepared from ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids by intramolecular Friedel-Crafts acylation promoted by bis(trichloromethyl) carbonate, in generally good yield without using Lewis acid catalysts.

• 出版日期2010-12-15