Individualized vitamin A supplementation for patients with cystic fibrosis

作者：Brei Christina; Simon Annette; Krawinkel Michael B; Naehrlich Lutz^*

来源：Clinical Nutrition, 2013, 32(5): 805-810.

DOI：10.1016/j.clnu.2013.01.009

• Cystic fibrosis
• Vitamin A
• Dietary supplements

Background %26 aims: To determine the vitamin A status and appropriate supplementation dosage of cystic fibrosis (CF) patients who received vitamin A supplementation based on annual serum retinol measurements. %26lt;br%26gt;Methods: Vitamin A food intake, supplementation dosage, and serum retinol levels were obtained for 32 CF patients %26gt;4 years of age (4.3-27.3 years old) who had pancreatic insufficiency and mild-to-moderate lung disease (percent predicted of forced expiratory volume in 1 s %26gt; 40%). These measurements were compared with the dietary reference intake for healthy children and adults (D-A-CH dietary recommendations), US and German CF recommendations, and serum retinol concentrations from National Health and Nutrition Examination Survey (NHANES) data. %26lt;br%26gt;Results: Total vitamin A intake from food and supplementation was 315% +/-182% of D-A-CH recommendations, with 65% from supplements. The range of the prescribed vitamin A supplementation dosage was 0-20,000 IU/day (median 5500 IU), and it was consistent with CF recommendations in 28% of participants. A quarter of all patients did not need any vitamin A supplementation. The total vitamin A intake exceeded the recommended upper limit of intake in 69% of subjects. The mean (range) serum retinol was 38.6 mu g/dl (22.1-59.1 mu g/dl). All subjects had serum retinol levels above 20 mu g/dl and below 72 mu g/dl (95th percentile of NHANES reference range). %26lt;br%26gt;Conclusion: Individualized vitamin A supplementation of 0-20,000 IU/day based on annual serum retinol measurements may prevent deficiency and high serum retinal levels, but it may lead to vitamin A intake above the tolerable upper intake level.

• 出版日期2013-10