Microwave-assisted Pd-catalyzed synthesis of fused steroidal and non-steroidal pyrimidines from beta-halo-alpha,beta-unsaturated aldehydes

作者：Gogoi Junali; Gogoi Pranjal^*; Bezbaruah Pranjal; Boruah Romesh C

来源：Tetrahedron Letters, 2013, 54(52): 7136-7139.

DOI：10.1016/j.tetlet.2013.10.094

• Heterosteroid
• Pyrimidine
• Unsaturated aldehyde
• Palladium
• Microwave

A Pd-catalyzed protocol has been developed for the synthesis of fused steroidal and non-steroidal pyrimidines from beta-halo-alpha,beta-unsaturated aldehydes under microwave irradiation. The beta-halo-alpha,beta-unsaturated aldehydes are synthesized from corresponding ketones using Vilsmeier formylation reaction. This synthetic protocol is utilized to synthesize some more novel steroidal pyrimidine derivatives and are currently being evaluated for their biological activities.

• 出版日期2013-12-25