MicroRNA-31 expression in colorectal serrated pathway progression

作者：Aoki Hironori; Nosho Katsuhiko^*; Igarashi Hisayoshi; Ito Miki; Mitsuhashi Kei; Naito Takafumi; Yamamoto Eiichiro; Tanuma Tokuma; Nomura Masafumi; Maguchi Hiroyuki; Shinohara Toshiya; Suzuki Hiromu; Yamamoto Hiroyuki; Shinomura Yasuhisa

来源：World Journal of Gastroenterology, 2014, 20(34): 12346-12349.

DOI：10.3748/wjg.v20.i34.12346

• BRAF
• Colorectal carcinoma
• MicroRNA-31
• MLH1
• microsatellite instability
• Serrated pathway

MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. Moreover, high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps (HPs). These results suggest that miR-31 may contribute to the progression of serrated lesions. At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features. Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component. Higher miR-31 expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa, suggesting that miR-31 may be one of the key molecules in serrated pathway progression.

• 出版日期2014-9-14