Antiviral and Anti-inflammatory Diterpenoids from the Soft Coral Sinularia gyrosa

作者：Cheng, Shi Yie; Chuang, Cheng Ta; Wang, Shang Kwei^*; Wen, Zhi Hong; Chiou, Shu Fen; Hsu, Chi Hsin; Dai, Chang Feng; Duh, Chang Yih

来源：Journal of Natural Products, 2010, 73(6): 1184-1187.

DOI：10.1021/np100185a

Chemical investigation of the salt coral Sinularia gyrosa led to the purification of three new diterpenoids. designated as gyrosanols A-C (1-3). The structures of 1-3 were elucidated through extensive spectroscopic analyses. Compounds 1 and 2 exhibited antiviral activity against HCMV with IC(50)'s of 2.6 and 3.7 mu M, respectively. In addition, compounds 1 and 2 showed significant anti-inflammatory activity by reducing the levels of the COX-2 protein (19.6 +/- 3.9% and 29.1 +/- 9.6%, respectively) in RAW 264.7 macrophages.

• 出版日期2010-6
• 单位中山大学