A label-free electrochemical assay for quantification of gene-specific methylation in a nucleic acid sequence

作者:Dai, Zong*; Hu, Xiao; Wu, Hai; Zou, Xiaoyong
来源:Chemical Communications, 2012, 48(12): 1769-1771.
DOI:10.1039/c2cc15398j

摘要

A label-free electrochemical method is developed for simple and convenient quantification of gene-specific DNA hypermethylation in a DNA sequence without PCR amplification, bisulfite conversion or labeling processes.