A(2A) adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats

作者：Di Bonaventura Maria V Micioni^*; Cifani Carlo; Lambertucci Catia; Volpini Rosaria; Cristalli Gloria; Massi Maurizio

来源：Behavioural Pharmacology, 2012, 23(5-6): 567-574.

DOI：10.1097/FBP.0b013e3283566a60

• A(2A) adenosine receptor
• A(2A) adenosine receptor agonists
• binge eating
• CGS 21680
• food deprivation-induced feeding
• high-palatability food intake
• low-palatability food intake
• rat
• VT 7

The present study examined the effect of two A(2A) adenosine receptor (AR) agonists, CGS 21680 and VT 7, on high-palatability food (HPF) intake in a model of binge eating in sated rats and on low-palatability food (LPF) intake in food-deprived rats. Binge eating was induced in female rats by three 8-day cycles of food restriction/refeeding, followed by acute stress. Two groups of rats were used: NR + NS rats normally fed and not stressed and R + S rats exposed to cycles of food restriction/refeeding and then stressed. R + S rats had higher intake of HPF than the NR + NS controls. The two A(2A)AR agonists were tested at doses of 0.1 and 0.05 mg/kg intraperitoneally; VT 7 did not modify locomotor activity at either dose, whereas CGS 21680 only slightly reduced it at the higher dose tested. The injection of 0.1 mg/kg of both agonists markedly reduced HPF intake both in R + S and in NR + NS rats. The dose of 0.05 mg/kg was inactive. CGS 21680 and VT 7, 0.1 mg/kg, also reduced the standard LPF intake in 24 h food-deprived rats; however, they did not reduce water intake, indicating that their effect on food intake is selective. The dose of 0.05 mg/kg was inactive. Thus, A(2A)AR agonists exert a rather general effect on food intake, inhibiting both HPF intake in sated rats and LPF intake in food-deprived rats. They may potentially be useful pharmacological agents to control binge-related eating disorders and to reduce food overconsumption associated with obesity.

• 出版日期2012-9