High adherence to all-oral directly acting antiviral HCV therapy among an inner-city patient population in a phase 2a study

作者：Petersen Tess; Townsend Kerry; Gordon Lori A; Sidharthan Sreetha; Silk Rachel; Nelson Amy; Gross Chloe; Calderon Monica; Proschan Michael; Osinusi Anu; Polis Michael A; Masur Henry; Kottilil Shyam^*; Kohli Anita

来源：Hepatology International, 2016, 10(2): 310-319.

DOI：10.1007/s12072-015-9680-7

• HCV
• DAA
• Adherence
• MEMS

As treatment for chronic hepatitis C (HCV) virus has evolved to all-oral, interferon-free directly acting antiviral (DAA) therapy, the impact of these improvements on patient adherence has not been described.
Medication adherence was measured in 60 HCV, genotype-1, treatment-na < ve participants enrolled in a phase 2a clinical trial at the National Institutes of Health and community clinics. Participants received either ledipasvir/sofosbuvir (LDV/SOF) (90 mg/400 mg) (one pill) daily for 12 weeks, LDV/SOF + GS-9451 (80 mg/day) (two pills) daily for 6 weeks, or LDV/SOF + GS-9669 (500 mg twice daily; three pills, two in the morning, one in the evening) for 6 weeks. Adherence was measured using medication event monitoring system (MEMS) caps, pill counts and patient report.
Overall adherence to DAAs was high. Adherence declined over the course of the 12-week treatment (p = 0.04). While controlled psychiatric disease or symptoms of depression did not influence adherence, recent drug use was a risk factor for non-adherence to 12-week (p = 0.01), but not 6-week regimens. Adherence as measured by MEMS was lower than by patient report.
Adherence to short courses of DAA therapy with 1-3 pills a day was excellent in an urban population with multiple risk factors for non-adherence.

• 出版日期2016-3
• 单位NIH