Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

作者：Smit Adriana L^*; Been Jasper V; Zimmermann Luc J I; Kornelisse Rene F; Andriessen Peter; Vanterpool Sizzle F; Bischoff Martijn P H; Stokroos Robert J; de Krijger Ronald R; Kremer Bernd; Kramer Boris W

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2015, 28(15): 1864-1869.

DOI：10.3109/14767058.2014.971747

• Automated auditory brainstem response
• chorioamnionitis
• hearing screening
• preterm infants

Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome.
Methods: Two cohorts of very preterm newborns (n = 548, gestational age <= 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome.
Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03).
Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.

• 出版日期2015