Association of Cyclin D1 Gene Polymorphisms With Risk of Esophageal Squamous Cell Carcinoma in Kashmir Valley-A High Risk Area

作者：Hussain Showket; Yuvaraj M; Thakur Nisha; Salam Irfana; Singh Neha; Mir Mohammad Muzaffar; Bhat Mohammad Akbar; Siddiqi Mushtaq A; Das Bhudev C; Bharadwaj Mausumi^*

来源：Molecular Carcinogenesis, 2011, 50(7): 487-498.

DOI：10.1002/mc.20732

• CCND1
• esophageal cancer
• Kashmir
• gene polymorphism

Investigation of potential association of SNPs (G870A, rs9344; G1722C, rs678653) of cyclin D1 gene (CCND1) with susceptibility to esophageal squamous cell carcinoma (ESCC) in Kashmir valley (India). The study included 302 subjects comprising 151 ESCC cases and 151 controls. PCR-RFLP and direct sequencing were employed for genotyping. The G870A polymorphism, the individuals carrying GA + AA genotype was having 2.80-fold increased risk for development of ESCC (OR 2.8, 95% CI = 1.77-4.4; P = 0.0001) compared to GG genotype. Further a significantly higher risk was observed in individuals who consume >3 cups per day of salted tea (OR = 5.1; 95% CI = 1.6-16.7; P = 0.0016) and had smoking habits (OR = 6.3; 95% CI 2.9-13.9; P = 0.0005). We also demonstrate for the first time in CCND1 1722 locus, the CC genotype was strongly associated with increased risk of developing ESCC (OR = 2.58; 95% CI = 1.61-4.15; P = 0.0001). In addition, the frequency of polymorphic C allele was also found to be higher in cases (OR = 1.92; 95% CI = 1.37-2.69; P = 0.0002). There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to ESCC.

• 出版日期2011-7
• 单位河北医科大学