Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial

作者：Espeland Mark A^*; Newman Anne B; Sink Kaycee; Gill Thomas M; King Abby C; Miller Michael E; Guralnik Jack; Katula Jeff; Church Timothy; Manini Todd; Reid Kieran F; McDermott Mary M

来源：Journal of the American Medical Directors Association, 2015, 16(8): 682-689.

DOI：10.1016/j.jamda.2015.03.010

• Cognitive function
• ankle-brachial index
• peripheral artery disease
• dementia

Objective: The objective of this study was to evaluate cross-sectional and longitudinal associations between ankle-brachial index (ABI) and indicators of cognitive function.
Design: Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial).
Setting: Eight US academic centers.
Participants: A total of 1601 adults ages 70-89 years, sedentary, without dementia, and with functional limitations.
Measurements: Baseline ABI and interviewer-and computer-administered cognitive function assessments were obtained. These assessments were used to compare a physical activity intervention with a health education control. Cognitive function was reassessed 24 months later (interviewer-administered) and 18 or 30 months later (computer-administered) and central adjudication was used to classify individuals as having mild cognitive impairment, probable dementia, or neither.
Results: Lower ABI had a modest independent association with poorer cognitive functioning at baseline (partial r = 0.09; P < .001). Although lower baseline ABI was not associated with overall changes in cognitive function test scores, it was associated with higher odds for 2-year progression to a composite of either mild cognitive impairment or probable dementia (odds ratio 2.60 per unit lower ABI; 95% confidence interval 1.06-6.37). Across 2 years, changes in ABI were not associated with changes in cognitive function.
Conclusion: In an older cohort sedentary individuals with dementia and with functional limitations, lower baseline ABI was independently correlated with cognitive function and associated with greater 2-year risk for progression to mild cognitive impairment or probable dementia.

• 出版日期2015-8-1
• 单位西北大学