Design and optimization of non-clogging counter-flow microconcentrator for enriching epidermoid cervical carcinoma cells

作者：Tran Minh Nhut; Dong Tao^*; Su Qianhua; Yang Zhaochu; Jakobsen Henrik; Karlsen Frank

来源：Biomedical Microdevices, 2011, 13(1): 179-190.

DOI：10.1007/s10544-010-9483-5

• Counter-flow
• Non-clogging
• Turbine blade
• Microconcentrator
• Artificial neuron network

Clogging failure is common for microfilters in living cells concentration; for instance, the CaSki Cell-lines (Epidermoid cervical carcinoma cells) utilizing the flat membrane structure. In order to avoid the clogging, counter-flow concentration units with turbine blade-like micropillar are proposed in microconcentrator design. Due to the unusual geometrical-profiles and extraordinary microfluidic performance, the cells blocking does not occur even at permeate entrances. A counter-flow microconcentrator was designed, with both processing layer and collecting layer arranged in terms of the fractal based honeycomb structure. The device was optimized by coupling Artificial Neuron Network (ANN) and Computational Fluid Dynamics (CFD). The excellent concentration ratio of a final microconcentrator was presented in numerical results.

• 出版日期2011-2