Neutrophil trails guide influenza-specific CD8(+) T cells in the airways

作者：Lim Kihong; Hyun Young Min; Lambert Emo Kris; Capece Tara; Bae Seyeon; Miller Richard; Topham David J; Kim Minsoo^*

来源：Science, 2015, 349(6252): aaa4352.

DOI：10.1126/science.aaa4352

During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.

• 出版日期2015-9-4
• 单位西北大学