Anti-biofilm efficacy of low temperature processed AgCl-TiO2 nanocomposite coating

作者：Naik Kshipra; Kowshik Meenal^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2014, 34: 62-68.

DOI：10.1016/j.msec.2013.10.008

• Low-temperature
• Sol-gel
• Silver-titania
• Nanocomposite
• Anti-biofilm

Biofilms are a major concern in the medical settings and food industries due to their high tolerance to antibiotics, biocides and mechanical stress. Currently, the development of novel methods to control biofilm formation is being actively pursued. In the present study, sol-gel coatings of AgCl-TiO2 nanoparticles are presented as potential anti-biofilm agents, wherein TiO2 acts as a good supporting matrix to prevent aggregation of silver and facilitates its controlled release. Low-temperature processed AgCl-TiO2 nanocomposite coatings inhibit biofilm formation by Escherichia coil, Staphylococcus epidermidis and pseudomonas aeruginosa. In vitro biofilm assay experiments demonstrated that AgCl-TiO2 nanocomposite coated surfaces, inhibited the development of biofilms over a period of 10 days as confirmed by scanning electron microscopy. The silver release kinetics exhibited an initial high release, followed by a slow and sustained release. The anti-biofilm efficacy of the coatings could be attributed to the release of silver, which prevents the initial bacterial adhesion required for biofilm formation.

• 出版日期2014-1-1