A priori, de novo mathematical exploration of gene expression mechanism via regression viewpoint with briefly cataloged modeling antiquity

作者：Jauhari Shaurya^*; Rizvi S A M

来源：International Journal of Biomathematics, 2017, 10(1): 1750006.

DOI：10.1142/S1793524517500061

• Gene expression
• method of least squares
• microarray
• normal equations
• regression
• transcription
• translation

Various algorithms have been devised to mathematically model the dynamic mechanism of the gene expression data. Gillespie's stochastic simulation (GSSA) has been exceptionally primal for chemical reaction synthesis with future ameliorations. Several other mathematical techniques such as differential equations, thermodynamic models and Boolean models have been implemented to optimally and effectively represent the gene functioning. We present a novel mathematical framework of gene expression, undertaking the mathematical modeling of the transcription and translation phases, which is a detour from conventional modeling approaches. These subprocesses are inherent to every gene expression, which is implicitly an experimental outcome. As we foresee, there can be modeled a generality about some basal translation or transcription values that correspond to a particular assay.

• 出版日期2017-1