BAFF Receptor Deficiency Reduces the Development of Atherosclerosis in Mice-Brief Report

作者：Sage Andrew P; Tsiantoulas Dimitrios; Baker Lauren; Harrison James; Masters Leanne; Murphy Deirdre; Loinard Celine; Binder Christoph J; Mallat Ziad^*

来源：Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32(7): 1573-1576.

DOI：10.1161/ATVBAHA.111.244731

• atherosclerosis
• cytokines
• immune system
• leukocytes
• transgenic models

Objective-The goal of this study was to assess the role of B-cell activating factor (BAFF) receptor in B-cell regulation of atherosclerosis. %26lt;br%26gt;Methods and Results-Male LDL receptor-deficient mice (Ldlr(-/-)) were lethally irradiated and reconstituted with either wild type or BAFF receptor (BAFF-R)-deficient bone marrow. After 4 weeks of recovery, mice were put on a high-fat diet for 6 or 8 weeks. BAFF-R deficiency in bone marrow cells led to a marked reduction of conventional mature B2 cells but did not affect the B1a cell subtype. This was associated with a significant reduction of dendritic cell activation and T-cell proliferation along with a reduction of IgG antibodies against malondialdehyde-modified low-density lipoprotein. In contrast, serum IgM type antibodies were preserved. Interestingly, BAFF-R deficiency was associated with a significant reduction in atherosclerotic lesion development and reduced numbers of plaque T cells. Selective BAFF-R deficiency on B cells led to a similar reduction in lesion size and T-cell infiltration but in contrast did not affect dendritic cell activation. %26lt;br%26gt;Conclusion-BAFF-R deficiency in mice selectively alters mature B2 cell-dependent cellular and humoral immune responses and limits the development of atherosclerosis. (Arterioscler Thromb Vasc Biol. 2012;32:1573-1576.)

• 出版日期2012-7