Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii

作者：Hirasawa Yusuke; Shoji Tomokazu; Arai Takashi; Nugroho Alfarius E; Deguchi Jun; Hosoya Takahiro; Uchiyama Nahoko; Goda Yukihiro; Awang Khalijah; Hadi A Hamid A; Shiro Motoo; Morita Hiroshi^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(6): 2021-2024.

DOI：10.1016/j.bmcl.2010.01.051

• Bisindole alkaloid
• Bisleuconothine A
• Leuconotis griffithii
• Cell growth inhibitory activity

A new bisindole alkaloid, bisleuconothine A(1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A(1) showed cell growth inhibitory activity against various human cancer cell lines.

• 出版日期2010-3-15