Analysis of risk factors in patients with leukoaraiosis

作者：Guan, Jiaxin; Yan, Chaoqi; Gao, Qiang; Li, Jun; Wang, Li; Hong, Ming; Zheng, Xiuhai; Song, Zhiqiang; Li, Mei; Liu, Meiling; Fan, Ying^*; Ma, Lan^*

来源：Medicine, 2017, 96(8): e6153.

DOI：10.1097/MD.0000000000006153

• age
• asymmetric dimethylarginine
• hypertension
• leukoaraiosis
• uric acid

To investigate the risk factors for leukoaraiosis (LA) and the correlation between risk factors and LA.
The study comprised 92 patients with diagnoses of LA (LA group) and 56 non-LA individuals (control group). Data were collected for the following: age, gender, fasting blood glucose, total cholesterol, triglyceride, high-and low-density lipoprotein cholesterol, uric acid, creatinine, and histories of smoking, hypertension, and diabetes. Levels of serum asymmetric dimethylarginine (ADMA) were detected by enzyme-linked immunosorbent assay.
Univariate analysis showed statistical significance between the 2 groups in age, histories of hypertension and smoking, uric acid, creatinine, and levels of serum ADMA (P<0.05). Binary logistic analysis showed that age (P<0.0001), hypertension (P=0.0101), and serum ADMA (P=0.0206) were related to LA. Pearson correlation analysis showed that levels of serum ADMA correlated with uric acid (r=0.184, P=0.025) and creatinine (r=0.169, P=0.04).
Age, hypertension, and levels of serum ADMA were independent risk factors for LA. Serum ADMA levels may be related to uric acid and creatinine.

• 出版日期2017-2
• 单位哈尔滨医科大学