Decreases in Inflammatory and Coagulation Biomarkers Levels in HIV-Infected Patients Switching from Enfuvirtide to Raltegravir: ANRS 138 Substudy

作者：Silva Erika F; Charreau Isabelle; Gourmel Bernard; Mourah Samia; Kalidi Issa; Guillon Brigitte; De Castro Nathalie; Caron Francois; Braun Josephine; Molina Jean Michel^*

来源：Journal of Infectious Diseases, 2013, 208(6): 892-897.

DOI：10.1093/infdis/jit280

• HIV
• enfuvirtide
• raltegravir
• IL-6
• CRP
• D-dimer
• switch
• biomarkers

Stored plasma specimens from 164 participants in the ANRS 138 trial were analyzed to determine interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels at baseline and weeks 24 and 48. These virologically suppressed, treatment-experienced patients were randomly assigned to undergo an immediate switch (IS) or a deferred switch (DS; at week 24) from an enfuvirtide-based antiretroviral therapy (ART) regimen to a raltegravir-based regimen. At week 24, a significant decrease from baseline was observed in the IS arm, compared with the DS arm, for IL-6 level (-30% vs +10%; P %26lt; .002), hsCRP level (-46% vs +15%; P %26lt; .0001), and D-dimer level (-40% vs +6%; P %26lt; .0001). At week 48, there was a reproducible decrease in levels of all biomarkers in the DS arm.

• 出版日期2013-9-15