科研之友
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摘要
Objective: To determine the relationship between beta-amyloid (A beta) load as measured by [C-11]-Pittsburgh compound B (PiB) PET and cognitive function in cognitively normal older adults. Methods: We studied 408 cognitively normal older adults who participated in the population-based Mayo Clinic Study of Aging (MCSA) from January 2009 through March 2011. The participants underwent PiB PET and neuropsychometric testing within 6 months. The association between PiB retention and cognitive function was measured by partial correlation and an interaction with APOE status was tested using linear regression after adjusting for age, sex, and education. Results: Higher PiB retention was associated with cognitive performance (Spearman partial r = -0.18; p < 0.01), specifically the memory, language, attention/executive, and visual-spatial processing domains in the whole group of participants. The association between PiB retention and cognition was modified by the APOE status on linear regression analysis even after controlling for the differences in the distribution of PiB values among APOE epsilon 4 carriers and noncarriers (p = 0.02). Cognitive performance was associated with the A beta deposition in the frontal, temporal, and parietal lobe association cortices in APOE epsilon 4 carriers on SPM analysis (p < 0.001). Conclusion: There is a modest association between PiB retention and cognitive function in cognitively normal older adults and this relationship between A beta load and cognitive function is modified by APOE status. Whereas A beta load is associated with greater cognitive impairment in APOE epsilon 4 carriers, the cognitive function in APOE epsilon 4 noncarriers is influenced less by the A beta load, suggesting that APOE isoforms modulate the harmful effects of A beta on cognitive function. Neurology (R) 2012; 78: 232-240
- 出版日期2012-1
